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KMID : 1144320100420030137
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감염과 화학요법
2010 Volume.42 No. 3 p.137 ~ p.142
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IgE-Mediated Hypersensitivity Reactions to Cephalosporins
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Kim Baek-Nam
Cho You-Sook
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Abstract
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Cephalosporins are commonly prescribed either orally or parenterally for the treatment of bacterial infections because of wide safety margin compared with penicillins. Skin testing with a parent cephalosporin antibiotic has routinely been performed in Korea in the fear of developing anaphylaxis after the administration of a cephalosporin although penicillins are antibiotics that most commonly induce severe or life-threatening IgE-mediated reactions (anaphylaxis). In this review, we will discuss IgE-mediated hypersensitivity reactions to cephalosporins. Immunopathogenesis of IgE-mediated hypersensitivity reaction to cephalosporins, limitations of skin testing with parent cephalosporin antibiotics, and prescription strategy of cephalosporins for patients with a history of cephalosporin or penicillin hypersensitivity was described.
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KEYWORD
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Cephalosporins, Penicillins, Hypersensitivity, Anaphylaxis
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